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Title: Comparison of diagnostic yield of full core and half core biopsy gun for liver lesions - A randomised controlled trial
e-poster Number: EPOS 3
Category: e Poster
Author Name: Dr. Tahleel Altaf Shera
Institute:
Co-Author Name:
Abstract :
Abstract
Purpose This study is aimed to evaluate the performance of conventional side cutting needles in comparison to newer core cutting needles in terms of Pathological Yield, Diagnostic Yield and Complications
Methods prospective randomized control study that included patients who underwent 18 gauge targeted core liver biopsy, 48 with BiopinceTM Ultra needle (Argon Medical) and 50 with MissionTM needle (BD Bard). Pathologist (blinded to needle type) reviewed specimen total length, maximum width, and weight of the specimen. A comparison of rates of major (requiring transfusion and/or embolization) and minor (self-limited bleeding) complications was done. The pathologist also made a comparison of adequacy of the specimen obtained in 2 groups. Comparison between needle types was performed using t-test.
Results For Biopince® and Mission® needles, the respective mean (SD) for total length(mm) was 16.88(1.04) and 14.38(3.80), p = 0.001; mean(SD) for diameter(mm) was 1.32(0.04) and 0.96(0.05), p=0.001; mean(SD) weight of largest core(mg) was 7.21(0.51) and 5(1.17) p=0.001 respectively and mean(SD) of weight of specimen (mg) was 35.15(9.22) and 25.38(10.21) p= 0.0001. Complication rates differed significantly between the two groups (p=0.008). The Full Core group had higher rates of minimal ascites (20.0%) compared to the Half Core group, which had no cases of minimal ascites. Pain was the most common complication in both groups. No major complications were seen in either group. The majority of specimens in both groups were labelled as average quality by pathologists
Conclusion The Full Core technique yielded longer and wider tissue cores, resulting in larger sample sizes that are crucial for accurate histopathological assessment. Despite the significant advantages in specimen quality and size, the diagnostic outcomes between the Full Core and Half Core groups were similar, indicating that both techniques are effective in clinical practice. However, the Full Core technique's ability to obtain more substantial tissue samples suggests it may be more reliable for cases in whom advanced investigations like IHC, mutations, gene sequencing are required ensuring that adequate material is available.
